The liver is the powerhouse for the process of blood clotting (hemostasis). Any damage to the liver, can affect the coagulation process, leading to further complications. It is thus important to choose an accurate testing kit that evaluates the changes to the coagulation markers and thus gives an indication of the severity of liver disease.
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Coagulation and fibrinolytic factors are universal indicators for detecting a liver impairment, the most accurate one being Prothrombin Time (PT). So, obviously it is critical to ensure that PT is evaluated with a quality diagnostic kit to ensure accuracy of reporting.
Criteria such as good ISI and precision in control (on a day-to-day basis), high linearity and correlation with reference reagents are essential while choosing a kit.
The Erba Protime LS from Transasia is a liquid stable, standardized, rabbit brain thromboplastin reagent with an excellent <1% CV and high linearity on serial dilution. When subjected to a correlation studies with other leading commercially available kits, Erba Protime LS proved to be an ideal choice for manual, semi and fully automated systems:
Correlation studies
Erba Protime LS was evaluated with two different reagents on
both the mechanical and optical system and was found to correlate well with r2=
0.9. (Figure 1 (A) & (B)).
Reagent A on “optical Figure 1 (A) |
Reagent B on “mechanical system” v/s Erba Protime Figure 1 (B) |
Erba Protime LS – the only kit with prolonged stability
Open vials of Erba Protime LS and two Erba controls were subjected to varying temperature conditions along with two other reagents and their controls. Erba Protime LS is the ONLY reagent kit that was found to be stable upto 60 days at 250C and upto 10 days at 370C. Considering the temperature diversity in India, Erba Protime LS with its prolonged stability is best suited for varying workloads
Erba Protime LS with control P (pic 1)
Erba Protime LS with control N (pic 2)
Interference Limits
Comparative studies have proved that Erba Protime LS has higher tolerance to various interfering factors compared to the other reagents available in the market.
graph
Conclusion
Erba Protime LS is a simple, inexpensive, quantitative and accurate kit for detection of PT, an essential marker for detection of liver disease.
