What notable IVD tech advancements have you seen in your career and their impact on diagnostics and care?
Ans: Over the course of my 30 years of experience in laboratory medicine, I have witnessed remarkable advancements. From the introduction of 3-part hematology analyzers to automated urine analyzers and fully automated molecular testing, the field has evolved tremendously. Today, we are benefiting from the integration of AI and digital imaging, enabling us to sign reports from our smartphones, share images with clinicians, and seek multiple second opinions on hematology, urine, and histopathology slides.
These advancements have had a profound impact on diagnostics and patient care:
There is a growing demand for accurate and precise reports delivered in the shortest turnaround time possible.
Technology has become more accessible to the general public, with cost-effective solutions available to a wider range of people.
The increased use of the internet and digital formats allows for real-time data access, significantly contributing to healthcare management.
Automation has proven to be a blessing for laboratory professionals, reducing analytical errors by a remarkable 4%.
Automation has not only influenced the analytical phase but also the pre-analytical and post-analytical phases, with the emergence of Total Laboratory Automation (TLA) and robotic labs in India. The laboratory industry is now being recognized as a key player, and efforts should be directed toward optimizing its impact on clinical outcomes.
How do you stay updated with evolving IVD tech and tools in this field?
Ans: Many In Vitro Diagnostics (IVD) companies are actively engaged in fostering a collaborative environment in the realm of scientific knowledge sharing. This cooperative approach is indeed commendable. IVD companies regularly host academic events and roundtable meetings, inviting global leaders to disseminate the latest technologies and emerging biomarkers within the field of laboratory medicine. Moreover, IVD websites serve as valuable platforms for educational resources, including webinars, white papers, and open-access journals, to facilitate learning and knowledge dissemination.
A notable stride in strengthening partnerships within the IVD sector involves collaborating with various professional associations. This strategic collaboration aims to enhance relationships with patients, laboratory professionals, pathologists, and physicians, thereby promoting a holistic and patient-centric approach to healthcare.
Please share cases where IVD tests were pivotal in diagnosis and patient care.
Ans: Here are some cases illustrating the pivotal role of In Vitro Diagnostic (IVD) tests in diagnosis and patient care:
HPLC/CE in Hemoglobinopathies: High-Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE) have revolutionized the identification of abnormal hemoglobin disorders such as thalassemia, sickle cell anemia, and hemoglobin C (HbC). Within a matter of minutes, these tests provide a comprehensive assessment. Notably, the government of India has recognized their significance by including them in the National Health Mission (NHM) to screen the population and target the eradication of sickle cell anemias by 2030.
Urine Automation: Automated urine tests are instrumental in the early detection of proteinuria and hematuria. These markers are vital for the timely diagnosis of glomerulonephritis, a condition that, when left untreated, can lead to renal failure. It is noteworthy that the Indian population has a significant prevalence of conditions like IgA nephropathy, lupus nephritis, drug-induced nephropathy, infectious nephritis, and nephrotic syndrome, particularly among younger individuals.
Hematology Analyzers: Today’s advanced hematology analyzers, offering extended parameters, are capable of providing over 16 reportable parameters, including research parameters. These analyzers play a crucial role in early detection of nutritional anemias, which significantly contribute to maternal mortality and diminished productivity, particularly in children and young IT professionals.
Clinical Chemistry/Immunoassays: IVD tests in clinical chemistry and immunoassays have introduced novel markers that enhance diagnostic accuracy. For instance, the use of Active B12 testing, which is superior to total B12 estimation, facilitates the early detection of Vitamin B12 deficiencies even before hematological manifestations occur. Such deficiencies are increasingly common in metropolitan areas due to the influence of a Westernized food culture. Additionally, the ability to detect ischemic heart disease through preventive stress-based High-Sensitivity Troponin I (HSTrop I) tests has become a valuable tool in managing cardiovascular health.
Please share your advice for aspiring IVD professionals and pathologists?
Ans: My advice for Pathologists:
Pathologists today should embrace the role of being “consultants to consultants.” As clinicians, they should actively engage in diagnostic stewardship and ensure the efficient utilization of laboratory resources. A solid foundation in all divisions of pathology is essential, and pathologists should continuously seek knowledge and be avid learners. A proficient pathologist can also make an exceptional physician, and their contributions are highly valued by various stakeholders, including IVD companies and healthcare organizations.
For IVD Professionals:
IVD professionals should embody a blend of skills encompassing biology, medicine, and technology, making them well-rounded and industry-ready. Actively participating in pathology, and medical conferences is vital for staying updated and honing their skills. The cultivation of skills is a crucial task for all IVD professionals, and fostering a culture of continuous learning is essential. Additionally, possessing strong soft skills and staying informed about medical affairs, especially those pertinent to local contexts, is indispensable for success in this field.
