Albumin, a major plasma protein, is synthesized in the liver from amino acids which are absorbed from the ileum. Its function includes regulation and distribution of extracellular fluid, transportation of various hormones, vitamins and trace metals. Increased levels are observed during dehydration due to reduced plasma water content. Even due to stasis during venipuncture which causes fluid to escape into the extravascular compartment. Decreased levels are observed during excessive protein loss (mainly albumin) - from kidney, skin or intestine. It can also occur during decreased synthesis due to dietary, hepatic disease or malabsorption or increased catabolism due to fever, untreated diabetes mellitus and hypertension.